The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrofluorimetric method for the simultaneous determination of Diclofenac potassium and Febuxostat in combined tablet dosage form. The derivative spectrofluorimetric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra were obtained in and the determinations were made at 384.160 nm (ZCP of Febuxostat) for Diclofenac potassium and 364.321 nm (ZCP of Diclofenac potassium) for Febuxostat. The linearity was obtained in the concentration range of 1000-5000 ng/ml for Diclofenac potassium and 400-2000 ng/ml for Febuxostat. The mean recovery was 99.87±0.77 and 99.95±0.46 for Diclofenac potassium and Febuxostat, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of Diclofenac potassium and Febuxostat in pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
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